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Identification of Neisseria gonorrhoeae as the Causative Agent in a Case of Culture-Negative Dermatitis–Arthritis Syndrome Using Real-Time PCR

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Sexually transmitted infections (STIs) are an increasingly common and important cause of a fever in a returning traveler. Systemic complications of STIs, human immunodeficiency virus seroconversion illness, and secondary syphilis are diagnoses that can easily be missed. We present a case of culture-negative disseminated gonococcal infection presenting with fever, malaise, polyarthralgia, arthritis, and a rash that developed following orogenital contact and was diagnosed using real-time polymerase chain reaction. This technology has major potential to improve the speed and sensitivity of diagnosis and consequent management of patients with this syndrome.
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Document Type: Research Article

Affiliations: 1: School of Biosciences, University of Westminster, London, UK 2: School of Infection & Host Defence, University of Liverpool, Liverpool, UK 3: Department of Clinical Microbiology 4: Infectious Diseases Unit 5: Department of Genitourinary Medicine, University Hospitals of Leicester, Leicester, UK

Publication date: September 1, 2008

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