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Commentary: Critical considerations for studying low‐functioning autism

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Jack and Pelphrey provide a systematic review of neuroimaging studies in understudied populations within the autistic spectrum, focussing specifically on those with minimal verbal ability, intellectual disability and developmental regression. Despite accounting for nearly a third of the autistic spectrum, the number of studies focussing on these populations is extremely low. This review highlights a critical need for further neuroimaging research on these populations, and provides practical suggestions for overcoming the challenges posed by it. In this commentary, I discuss some of the theoretical questions that arise from the review, on the conceptualisation of the autistic spectrum as well as on optimising experimental design and analysis. Read the full article at doi: 10.1111/jcpp.12687
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Keywords: Autism spectrum disorders; cognitive impairment; functional MRI; nosology; research design

Document Type: Research Article

Publication date: April 1, 2017

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