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Cognitive impairments are different in single‐incidence and multi‐incidence ADHD families

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We may improve our understanding of the role of common versus unique risk factors in attention‐deficit/hyperactivity disorder (ADHD) by examining ADHD‐related cognitive deficits in single‐ (SPX), and multi‐incidence (MPX) families. Given that individuals from multiplex (MPX) families are likely to share genetic vulnerability for the disorder, whereas simplex (SPX) ADHD may be the result of sporadic (non‐)genetic causes unique to the patient, we hypothesized that cognitive impairments may be different in SPX and MPX ADHD as indicated by (a) the presence of cognitive deficits in MPX, but not SPX unaffected siblings and (b) dissimilar cognitive profiles in SPX and MPX ADHD patients.
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Keywords: Attention‐Deficit/Hyperactivity Disorder (ADHD); endophenotype; family; simplex‐multiplex stratification; unaffected relative

Document Type: Research Article

Publication date: July 1, 2015

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