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Taylor's Cortical Dysplasia: A Confocal and Ultrastructural Immunohistochemical Study

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In the present report we describe the neuropathological characteristics of tissue surgically resected from three patients affected by intractable epilepsy secondary to cortical dysplasia. Common features, suggestive of a focal cortical dysplasia of Taylor, were observed in all specimens. Immunocytochemical procedures were performed using neuronal and glial markers and the sections were observed at light traditional and confocal microscopes. This part of the investigation pointed out: 1. cortical laminar disruption; 2. very large neurons displaying a pyramidal or round shape; 3. ballooned cells; 4. decrease of calcium binding proteins immunoreactivity; 5. abnormal nets of parvalbumin‐ and glutamic acid decarboxylase‐positive puncta around giant neurons but not around ballooned cells. Ultrastructural investigation on the same material provided evidence of a high concentration of neurofilaments in giant neurons and of glial intermediate filaments in ballooned cells. In addition, immunolabeled GABAergic terminals clustered around giant neurons were not found to establish synapses on their cell bodies.
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Document Type: Research Article

Affiliations: 1: Department of Experimental Neurophysiology and Epileptology, National Neurological Institute “C. Besta”, Milan, Italy 2: Department of Epilepsy Surgery, Niguarda Hospital, Milan and Department of Neurosurgery, University of Genoa, Italy 3: Department of General Physiology and Biochemistry, Section of Histology and Human Anatomy, University of Milan, Italy.

Publication date: July 1, 1999

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