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Publisher: Wiley-Blackwell

Volume 39, Number 3, 1 March 2018

Application of a physiologically‐based pharmacokinetic model for the prediction of bumetanide plasma and brain concentrations in the neonate
pp. 125-134(10)
Authors: Donovan, Maria D.; Abduljalil, Khaled; Cryan, John F.; Boylan, Geraldine B.; Griffin, Brendan T.

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Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug–drug interaction potential of CYP3A4 substrates
pp. 152-163(12)
Authors: Umehara, Ken‐ichi; Huth, Felix; Won, Christina S.; Heimbach, Tycho; He, Handan

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An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW‐2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins
pp. 164-174(11)
Authors: Hosogi, Jun; Ohashi, Rui; Maeda, Hiroshi; Fujita, Kazuhiro; Ushiki, Junko; Kuwabara, Takashi; Yamamoto, Yorihiro; Imamura, Toru

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Differences in nonclinical pharmacokinetics between species and prediction of human pharmacokinetics of TAK‐272 (SCO‐272), a novel orally active renin inhibitor
pp. 175-183(9)
Authors: Ebihara, Takuya; Nishihara, Mitsuhiro; Takahashi, Junzo; Jinno, Fumihiro; Tagawa, Yoshihiko

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