Skip to main content
padlock icon - secure page this page is secure

Purification, crystallization and preliminary X‐ray diffraction analysis of crotamine, a myotoxic polypeptide from the Brazilian snake

Buy Article:

$52.00 + tax (Refund Policy)

Crotamine, a highly basic myotoxic polypeptide (molecular mass 4881 Da) isolated from the venom of the Brazilian rattlesnake Crotalus durissus terrificus, causes skeletal muscle contraction and spasms, affects the functioning of voltage‐sensitive sodium channels by inducing sodium influx and possesses antitumour activity, suggesting potential pharmaceutical applications. Crotamine was purified from C. durissus terrificus venom; the crystals diffracted to 1.9 Å resolution and belonged to the orthorhombic space group I212121 or I222, with unit‐cell parameters a = 67.75, b = 74.4, c = 81.01 Å. The self‐rotation function indicated that the asymmetric unit contained three molecules. However, structure determination by molecular replacement using NMR‐determined coordinates was unsuccessful and a search for potential derivatives has been initiated.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Publication date: September 1, 2012

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more