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Crystallization and preliminary crystallographic characterization of three peptidic inhibitors in complex with α‐thrombin

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The serine protease thrombin plays a major role in thrombosis and haemostasis. This has driven interest in thrombin inhibitors as potential antithrombotic drugs. Here, the crystallization and preliminary crystallographic analysis of human α‐thrombin in complex with three noncovalent peptide inhibitors of the general sequence d‐Phe‐Pro‐d‐Arg‐P1′‐CONH2 are reported. The crystals belonged to the orthorhombic space group P212121 and diffracted to beyond 1.3 Å resolution.
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Keywords: blood coagulation; noncovalent; peptide inhibitors; thrombin

Document Type: Research Article

Publication date: January 1, 2011

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