Cloning, expression, purification, crystallization and preliminary X‐ray studies of a secreted lectin (Rv1419) from Mycobacterium tuberculosis
A secreted lectin, Rv1419, from Mycobacterium tuberculosis has been cloned, expressed, purified and crystallized and the crystals have been characterized. This represents the first X‐ray investigation of a lectin or lectin‐like molecule from the pathogen. The cubic crystals contain one molecule in the asymmetric unit. Sequence comparisons indicate that the lectin has a β‐trefoil fold and belongs to a well characterized family of carbohydrate‐binding modules. Structural analysis of the crystals is in progress.
No Supplementary Data
No Article Media