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Structure of the thioredoxin‐fold domain of human phosducin‐like protein 2

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Human phosducin‐like protein 2 (hPDCL2) has been identified as belonging to subgroup II of the phosducin (Pdc) family. The members of this family share an N‐terminal helix domain and a C‐terminal thioredoxin‐fold (Trx‐fold) domain. The X‐ray crystal structure of the Trx‐fold domain of hPDCL2 was solved at 2.70 Å resolution and resembled the Trx‐fold domain of rat phosducin. Comparative structural analysis revealed the structural basis of their putative functional divergence.
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Keywords: phosducin family; phosducin‐like protein 2; thioredoxin fold

Document Type: Research Article

Publication date: February 1, 2009

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