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Crystallization and preliminary X‐ray data analysis of β‐alanine synthase from Drosophila melanogaster

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β‐Alanine synthase catalyzes the last step in the reductive degradation pathway for uracil and thymine, which represents the main clearance route for the widely used anticancer drug 5‐fluorouracil. Crystals of the recombinant enzyme from Drosophila melanogaster, which is closely related to the human enzyme, were obtained by the hanging‐drop vapour‐diffusion method. They diffracted to 3.3 Å at a synchrotron‐radiation source, belong to space group C2 (unit‐cell parameters a = 278.9, b = 95.0, c = 199.3 Å, β = 125.8°) and contain 8–10 molecules per asymmetric unit.
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Keywords: amidohydrolases; pyrimidine degradation; β‐alanine synthesis

Document Type: Research Article

Publication date: October 1, 2007

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