Skip to main content
padlock icon - secure page this page is secure

Crystallization and preliminary X‐ray diffraction analysis of hemextin A: a unique anticoagulant protein from Hemachatus haemachatus venom

Buy Article:

$52.00 + tax (Refund Policy)

Hemextin A was isolated and purified from African Ringhals cobra (Hemachatus haemachatus). It is a three‐finger toxin that specifically inhibits blood coagulation factor VIIa and clot formation and that also interacts with hemextin B to form a unique anticoagulant complex. Hemextin A was crystallized by the hanging‐drop vapour‐diffusion method by equilibration against 0.2 M ammonium acetate, 0.1 M sodium acetate trihydrate pH 4.6 and 30% PEG 4000 as the precipitating agent. The crystals belong to space group P212121, with unit‐cell parameters a = 49.27, b = 49.51, c = 57.87 Å and two molecules in the asymmetric unit. They diffracted to 1.5 Å resolution at beamline X25 at BNL.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: anticoagulants; hemextin; snake‐venom toxins; three‐finger toxins

Document Type: Research Article

Publication date: August 1, 2007

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more