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Purification, crystallization and preliminary X‐ray diffraction studies of Rab11 in complex with Rab11‐FIP2

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The small GTPase Rab11 regulates the recycling of endosomes back to the plasma membrane. In its active GTP‐bound form, Rab11 binds a novel set of effectors termed the Rab11 family of interacting proteins (Rab11‐FIPs) which contain a conserved C‐terminal Rab‐binding domain (RBD) of unknown structure. Here, a complex of Rab11 with the RBD of Rab11‐FIP2 has been purified and crystallized in the trigonal space group P3121, with unit‐cell parameters a = 64.99, b = 64.99, c = 112.59 Å. Static light‐scattering analyses of the molecular weight of the complex in solution are consistent with two copies of Rab11 and two copies of Rab11‐FIP2 in the complex.
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Keywords: GTPases; Rab11; Rab11 family of interacting proteins

Document Type: Research Article

Publication date: July 1, 2006

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