Skip to main content
padlock icon - secure page this page is secure

X‐ray structure of glutathione S‐transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate‐binding site

Buy Article:

$52.00 + tax (Refund Policy)

The crystal structure of the 26 kDa glutathione S‐transferase from Schistosoma japonicum (SjGST) was determined at 3 Å resolution in the new space group P212121. The structure of orthorhombic SjGST reveals unique features of the ligand‐binding site and dimer interface when compared with previously reported structures. SjGST is recognized as the major detoxification enzyme of S. japonicum, a pathogenic helminth causing schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable for the development of novel drugs.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: H‐site; Schistosoma japonicum; glutathione S‐transferase; inhibitor

Document Type: Research Article

Publication date: March 1, 2005

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more