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Chronological and Morphological Study of Heart Development in the Rat

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Abstract

Adult and embryonic laboratory rats have been used as a mammalian model organism in biomedical research, descriptive and experimental cardiac embryology, and experimental teratology. There have been, however, considerable variations and discrepancies concerning the developmental staging of the rat embryo in the reported literature, which have resulted in several controversies and inconsistencies. Therefore, we carried out a careful anatomical and histological study of rat cardiac morphogenesis from the premorphogenetic period to the mature heart in a newborn pup. A correlation between the chronology and morphological features of the heart and embryo or newborn was made. We provide a simple and comprehensive guide relating the developmental timing and fate of the embryonic components of the heart and their morphological changes in the rat based on in vivo labeling studies in the chick. We also compare the timing of heart development in rats, humans, and mice. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
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Document Type: Research Article

Affiliations: 1: Unidad de Investigación en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social 2: Colegio Ciencia y Tecnología, Universidad Autónoma de la Ciudad de México, UACM 3: Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Campus UNAM-Juriquilla 4: División de Investigación Biomédica, Subdirección de Enseñanza e Investigación, CMN "20 de Noviembre", ISSSTE 5: Laboratorio de Investigación en Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez

Publication date: 01 August 2012

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