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Simultaneous stimulation of growth hormone, adrenocorticotropin and cortisol with L‐dopa/L‐carbidopa and propranolol in children of short stature

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In 59 otherwise healthy children of short stature, the simultaneous response of growth hormone, cortisol and plasma adrenocorticotropin (ACTH) to L‐dopa/L‐carbidopa and propranolol at 45 and 90min after administration were investigated. A growth hormone response of 10 μg/l or higher was considered positive. The definition of a positive cortisol response included either a hormone increase of at least 193 nmol/l or a peak hormone level of at least 497 nmol/l. The ACTH increase had to be fourfold above 11 pmol/l to be considered positive. In the 59 investigated children, the median basal growth hormone levels increased from 1.35 p.g/l to 18.05 ug/l and 10.15 p.g/l at 45 and 90 min after stimulation (p <0.05). The median cortisol levels rose from 242 nmol/l to 439 nmol/l and 612 pmol/l, and the corresponding median ACTH levels from 2.94 pmol/l to 9.63 pmol/l and 11.13 pmol/l at 45 and 90 min after stimulation. Significant positive hormone response rates were 88.1% for growth hormone, 88.1% for cortisol and 69% for ACTH. These results could be attributed to the enhanced stimulating effect of the additional administration of L‐carbidopa and propranolol.
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Keywords: Adrenocorticotropin; cortisol; growth hormone; modified L‐dopa‐test; pituitary hormone stimulation

Document Type: Research Article

Affiliations: 1: Departments of Nuclear, Johannes Gutenberg University, Mainz, Germany 2: Departments of Medicine, Johannes Gutenberg University, Mainz, Germany

Publication date: April 1, 2000

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