Skip to main content
padlock icon - secure page this page is secure

Simultaneous stimulation of growth hormone, adrenocorticotropin and cortisol with L‐dopa/L‐carbidopa and propranolol in children of short stature

Buy Article:

$52.00 + tax (Refund Policy)

In 59 otherwise healthy children of short stature, the simultaneous response of growth hormone, cortisol and plasma adrenocorticotropin (ACTH) to L‐dopa/L‐carbidopa and propranolol at 45 and 90min after administration were investigated. A growth hormone response of 10 μg/l or higher was considered positive. The definition of a positive cortisol response included either a hormone increase of at least 193 nmol/l or a peak hormone level of at least 497 nmol/l. The ACTH increase had to be fourfold above 11 pmol/l to be considered positive. In the 59 investigated children, the median basal growth hormone levels increased from 1.35 p.g/l to 18.05 ug/l and 10.15 p.g/l at 45 and 90 min after stimulation (p <0.05). The median cortisol levels rose from 242 nmol/l to 439 nmol/l and 612 pmol/l, and the corresponding median ACTH levels from 2.94 pmol/l to 9.63 pmol/l and 11.13 pmol/l at 45 and 90 min after stimulation. Significant positive hormone response rates were 88.1% for growth hormone, 88.1% for cortisol and 69% for ACTH. These results could be attributed to the enhanced stimulating effect of the additional administration of L‐carbidopa and propranolol.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Adrenocorticotropin; cortisol; growth hormone; modified L‐dopa‐test; pituitary hormone stimulation

Document Type: Research Article

Affiliations: 1: Departments of Nuclear, Johannes Gutenberg University, Mainz, Germany 2: Departments of Medicine, Johannes Gutenberg University, Mainz, Germany

Publication date: April 1, 2000

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more