@article {STRANDVIK:1989:0803-5253:58,
title = "Relation between Essential Fatty Acid Metabolism and Gastrointestinal Symptoms in Cystic Fibrosis",
journal = "Acta Pædiatrica",
parent_itemid = "infobike://bpl/apa",
publishercode ="bp",
year = "1989",
volume = "78",
number = "1",
publication date ="1989-11-01T00:00:00",
pages = "58-65",
itemtype = "ARTICLE",
issn = "0803-5253",
eissn = "1651-2227",
url = "https://www.ingentaconnect.com/content/bpl/apa/1989/00000078/a363s363/art00012",
doi = "doi:10.1111/apa.1989.78.s363.58",
keyword = "arachidonic acid, pancreas, liver, intestine, eicosanoids, linoleic acid",
author = "STRANDVIK, B.",
abstract = "Studies in our laboratory have supported the hypothesis, that the basic defect in cystic fibrosis increases the metabolism of essential fatty acids and thereby gradually gives rise to essential fatty acid deficiency, which is a well documented finding in most cases with this disease.
Both the increased metabolismgiving high liberation of arachidonic acid and its metabolic products, i.e. different eicosanoidsand the subsequent essential fatty acid deficiency will cause gastrointestinal symptoms and the sequence of this development will mirror the natural history
of the disease. Clinical data and results from animal research are discussed in relation to gastrointestinal symptoms and signs of cystic fibrosis.",
}