Host Response to Pseudomonas aeruginosa
Patients with cystic fibrosis (CF) do not reveal a primary immune defect and respond with high numbers of functional polymorphonuclear leukocytes (PMN) and specific antibodies to lung infection with Pseudomonas aeruginosa. The mucoid character of P. aeruginosa, an altered epithelial cell surface, and high concentrations of PMN‐derived lysosomal enzymes contribute to impaired bacterial lung clearance and result in chronic infection. Released PMN‐elastase inactivates exotoxin A, the major toxin of P. aeruginosa, thus reducing its virulence. The imbalance between PMN‐proteinases and their inhibitors leads to lung tissue damage, impaired opsonophagocytosis, and T‐cell and B‐cell imbalance. New therapeutical concepts in CF therefore combine anti‐inflammatory drugs with effective antibiotics.
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Document Type: Research Article
Affiliations: From the Department of General and Environmental Hygiene, Hygiene-Institute, University of Tübingen, Silcherstrasse 7. D-7400 Tübingen, FRG
Publication date: November 1, 1989