Skip to main content
padlock icon - secure page this page is secure

Host Response to Pseudomonas aeruginosa

Buy Article:

$52.00 + tax (Refund Policy)

Patients with cystic fibrosis (CF) do not reveal a primary immune defect and respond with high numbers of functional polymorphonuclear leukocytes (PMN) and specific antibodies to lung infection with Pseudomonas aeruginosa. The mucoid character of P. aeruginosa, an altered epithelial cell surface, and high concentrations of PMN‐derived lysosomal enzymes contribute to impaired bacterial lung clearance and result in chronic infection. Released PMN‐elastase inactivates exotoxin A, the major toxin of P. aeruginosa, thus reducing its virulence. The imbalance between PMN‐proteinases and their inhibitors leads to lung tissue damage, impaired opsonophagocytosis, and T‐cell and B‐cell imbalance. New therapeutical concepts in CF therefore combine anti‐inflammatory drugs with effective antibiotics.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: From the Department of General and Environmental Hygiene, Hygiene-Institute, University of Tübingen, Silcherstrasse 7. D-7400 Tübingen, FRG

Publication date: November 1, 1989

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more