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Co(II), Ni(II), Cu(II) and Zn(II) complexes of isatinyl‐2‐aminobenzoylhydrazone: synthesis, characterization and anticancer activity

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This article describes the synthesis, structural aspects and biological studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of a new hydrazone derived from the condensation of isatin and 2‐aminobenzoylhydrazide. The ligand is well characterized using 1H NMR, 13C NMR, 2D HETCOR, mass and IR spectral studies. The chelating tendency of the ligand towards transition metal ions is established using analytical and spectral studies, which reveal the monobasic tridentate nature of the ligand. Octahedral geometry for Co(II), Cu(II) and Zn(II) and tetrahedral geometry for Ni(II) are tentatively proposed. All the synthesized compounds were screened for in vitro anticancer activity against Ehrlich ascites carcinoma and human cancer cell lines (adenocarcinoma HT29, kidney cancer cell line K293 and breast cancer cell line MDA231) using tryphan blue exclusion method and MTT assay. Copyright © 2014 John Wiley & Sons, Ltd. Transition metal complexes of a new ligand 2‐aminobanzoyl isatin hydrazone have been synthesized and both ligand and complexes characterized using 1H, 13C, 2D HETCOR, mass and IR spectral studies. Analysis reveals the monobasic tridentate nature of the ligand. In vitro anticancer activity of compounds is carried out against human cancer cell lines (adenocarcinoma HT29, kidney cancer cell line K293 and breast cancer cell line MDA231) using Tryphan blue exclusion method and MTT assay.
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Keywords: 2‐aminobenzoylhydrazone; anticancer activity; hydrazone; isatin; transition metal complex

Document Type: Research Article

Publication date: February 1, 2015

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