18‐Crown‐6 promoting Pd/C‐catalyzed cross‐coupling reaction of aryl bromides and arylboronic acids in aqueous media
Pd/C‐catalyzed Suzuki–Miyaura cross‐coupling between aryl bromides and arylboronic acids in 50% methanol aqueous solution proceeded smoothly in the presence of 18‐crown‐6. Various aryl bromides bearing electron‐withdrawing groups and electron‐donating groups coupled with arylboronic acid in high yields. In addition, the catalyst could be recycled five times without loss of activity. Copyright © 2012 John Wiley & Sons, Ltd.
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Document Type: Research Article
Publication date: September 1, 2012