Skip to main content
padlock icon - secure page this page is secure

Increased cardiovascular mortality and suicide after methyl chloride exposure

Buy Article:

$52.00 + tax (Refund Policy)

Abstract
Objectives

Methyl chloride leakage from a refrigerator occurred on board an Icelandic fishing vessel in 1963. Many of the crew members were hospitalized due to various neurological symptoms and signs. The aim was to study long‐term mortality.
Methods

This is a cohort study. Five referents were selected from registries of deckhands and officers matched to each crew member according to age and occupation. Follow‐up was through record linkage of personal identifiers with the nation‐wide mortality registry. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated in Cox proportional hazards model.
Results

The intoxicated crew was composed of 20 deckhands and 7 officers; the reference group counted 100 deckhands and 35 officers. Follow‐up to the end of 2010; 14 of the exposed deckhands and 6 of the officers had died, versus 49 deckhands and 26 officers among the reference group. For all cardiovascular events, the HR was 2.06 (95% CI 1.02–4.15), for acute coronary heart disease, the HR was 3.12 (95% CI 1.11–8.78), for cerebrovascular diseases, the HR was 5.35 (1.18–24.35), and for suicide, the HR was 13.76 (1.18–160.07).
Conclusions

Follow‐up showed increased mortality due to cardiovascular diseases after 47 years. The suicide cases had developed severe depression after the methyl chloride intoxication that was related to the exposure. The use of the personal identifiers and the population registries strengthen the study. Detailed information on risk factors for chronic diseases is lacking in this study; however, the matching by occupation renders some similarity to the groups compared in the study. Am. J. Ind. Med. 57:108–113, 2014. © 2013 Wiley Periodicals, Inc.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Publication date: January 1, 2014

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more