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High hsCRP is associated with reduced lung function in structural firefighters

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To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters.

We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high‐sensitivity C‐reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1 s (FEV1%‐predicted) and forced vital capacity (FVC%‐predicted).

Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10‐hsCRP, FEV1%‐predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%‐predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%).

hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters. Am. J. Ind. Med. 57:31–37, 2014. © 2013 Wiley Periodicals, Inc.
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Document Type: Research Article

Publication date: January 1, 2014

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