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High hsCRP is associated with reduced lung function in structural firefighters

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Abstract
Background

To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters.
Methods

We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high‐sensitivity C‐reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1 s (FEV1%‐predicted) and forced vital capacity (FVC%‐predicted).
Results

Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10‐hsCRP, FEV1%‐predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%‐predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%).
Conclusion

hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters. Am. J. Ind. Med. 57:31–37, 2014. © 2013 Wiley Periodicals, Inc.
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Document Type: Research Article

Publication date: January 1, 2014

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