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Antihypertensive Effect of Sesamin

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Sesamin is one of the lignans found in high concentration in sesame seeds and oil. Several studies have demonstrated the protective effects of sesamin against the liver injury, which is mainly due to its antioxidative activity. However, little is known about the biological activities of sesamin in cardiovascular system. We have recently obtained evidence that dietary sesamin efficiently suppressed the development and maintenance of hypertension in deoxycorticosterone acetate (DOCA)-salt-induced hypertensive, two-kidney, one-clip renal hypertensive, and salt-loaded stroke-prone spontaneously hypertensive rats. The suppressive effect of sesamin on blood pressure elevation was closely related to an inhibitory effect on excessive superoxide (O2 -) production in the aorta of hypertensive animals. In addition, dietary sesamin normalized the decrease in endothelium-dependent vasodilatory responses and the increase in α1- adrenoceptor-dependent vasoconstrictor responses in DOCA-salt hypertensive model. We propose that the dietary sesamin is useful as a prophylactic treatment in the development of hypertension and endothelial dysfunction, and suggest that the antioxidative property of sesamin may apply to the prevention of oxidative stress-related diseases, such as diabetes, hypercholesterolemia, and atherosclerosis.
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Keywords: endothelial dysfunction; hypertension; sesamin; superoxide

Document Type: Review Article

Affiliations: Department of Pharmacology,Osaka University of Pharmaceutical Sciences; 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

Publication date: November 1, 2004

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  • Vascular Disease Prevention publishes reviews as well as original papers to update all those concerned with this topic at the clinical or scientific level. In addition to clinically relevant topics, we consider reviews and original papers dealing with the more scientific aspects of vascular disease prevention. This includes the evaluation of emerging vascular risk factors, research dealing with the pathogenesis of atherosclerosis and the investigation of new treatment options both at the clinical and scientific level (e.g. epidemiology, patient-based studies, experimental models, in vitro experiments or molecular research). Therefore, another function of Vascular Disease Prevention is to bridge the gap between clinical practice and ongoing laboratory-based research.

    In particular, we welcome critical reviews and comments on recent trials. This is a topic that requires regular updates because of the large number of trials published every year.

    Debates are encouraged in the correspondence section of this journal.
    The editorial structure of Vascular Disease Prevention is set up with the aim of dealing with the submitted material as rapidly as possible. Specialist editors will provide a more expert and rapid assessment unlike a more centralized editorial structure.
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