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Therapeutic Approaches of Leptin in Alzheimer's Disease

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Novel approaches in the understanding of the neurodegeneration observed in Alzheimer's disease (AD), involving neurochemical as well as biochemical techniques are being developed, opening up new possibilities in the direction of a metabolic degeneration. Indeed, brain lipids are closely involved in amyloid β-related pathogenic pathways. An important modulator of lipid homeostasis is the pluripotent peptide leptin, which has been shown to reduce amyloid β levels and tau-related pathological pathways, the major pathological hallmarks of AD. These data suggest that leptin holds promise as a novel therapeutic tool for AD. In this article, with some patent literature we will review here some of the most promising approaches involving leptin to cure and prevent, rather than to treat, AD symptoms.

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Keywords: Alzheimer's disease; amyloidosis; blood-brain barrier; cardiovascular risk factors; choroid plexus; hyperphosphorylated tau; leptin; megalin; metabolic syndrome; neurogenesis; neurons; neuroprotection; obesity; synapses; transgenic mice

Document Type: Research Article

Publication date: November 1, 2009

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  • Recent Patents on CNS Drug Discovery publishes review articles on recent patents in the field of CNS drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on CNS drug discovery is also included in the journal. The journal is essential reading for all researchers involved in CNS drug design and discovery.
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