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Antileishmanial Patents Antileishmanial Current Drugs and Relevant Patents

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The World Health Organization has classified the leishmaniasis as a major tropical disease. An effective vaccine is not available and the chemotherapy is the only effective way to treat all forms of disease. Currently, the therapy is toxic, expensive and the resistance has emerged as a serious problem, which has compelled the search for new antileishmanial agents. The aim of this article is to review the recent advances in antileishmanial drugs. In addition, patents from 01/1969 to 12/2009 were analyzed. After initial review, 867 patents were classified as vaccines, immunomodulators and drugs. Among them, the major percent was reached by the drugs, accounting for 68% of the patents. In this review, 580 patents were listed, reviewed and classified according the approach of the inventors in the expansion of antileishmanial drug discovery. In this moment, the scenario of leishmaniasis chemotherapy is more promising than ever. Nevertheless, advances in the understanding of new metabolic pathways and drug targets in the parasite could offer new alternatives to treatment of leishmaniasis.





Keywords: Abelcet; Actonel; Alkylphospholipid; AmBisome; Aminoglycosides; Amphocil; Amphotericin; Artemisia annua; DNDi; Drugs; Fosamax; L. braziliensis; L. infantum; L. major; Leishmania; Lutzomyia; Pentostam; Phlebotomus; Plasmodium vivax; Pneumocystis carinii; Polyenic macrolide; Pseudomonas syringae; Simaroubaceae family; Trypanosoma; amastigote; antileishmanial agents; antiparasitic; cardiotoxicity; chemotherapy; consortia; cysteine proteases; deaminase; dihydroartemisinin; dihydroartemisitene; drug; flagellum; fluconazole; human immunodeficiency virus; immunomodulators; itrakonazole; ketoconazole; leishmaniasis; lipoxygenase; miltefosine; paromomycin; patents; phocholines; posaconazole; post-kala azar; protozoan; purine nucleoside; pyrimidine nucleoside; pyrophosphate synthase; quassinoids; recidivans; sodium stibogluconate; vaccination; vaccine

Document Type: Research Article

Publication date: January 1, 2011

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  • Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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