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Syntheses Of Neurotensin (Nt) Analogues And Their Comparative Anorectic Effect On Food Intake In Rats

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Five analogues of neurotensin(NT:Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) were prepared by the solid-phase method and their comparative anorectic effects on food intake in rats were examined. Among them, [Phe(NO2)3,11]-NT and [Phe(4F)3,11]-NT showed stronger anorectic activity than that of the parent peptide but [Tyr(Me)3,11]-NT was less active than the parent peptide. On the contrary, the other two analogues, [Sar7,10]-NT and [beta Ala7,10]-NT had no anorectic activity.
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Keywords: NEUROTENSIN (NT) ANALOGUES; Neurotensin (NT); anorectic activity

Document Type: Review Article

Publication date: December 1, 2001

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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