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Fish Gelatin Hydrolysates as Antioxidant, Antihypertensive, and Antidiabetic: The Plausible Mechanisms

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Gelatin produced from fish processing by-product is the most potential alternative source of gelatin. They have biological activities, particularly antioxidant, antihypertensive, and reduce type 2 diabetic risk. This paper reviews the mechanisms of fish gelatin hydrolysates for those human diseases being discussed in recent studies. Based on the review, mostly, skin and bone are used as sources of fish-based gelatin in which about thirty percent comes from the weight of total fish. Some species have been analysed based on their bioactivities, including Tuna, Nile tilapia, Amur sturgeon, Pangasius catfish, Cod, Blacktip shark, Salmon, Halibut, and Tilapia fish. In short, the antioxidant mechanism of this fish-based gelatin is by scavenging and neutralizing the radicals. The antihypertensive mechanism is by inhibition of Angiotensin-Converting Enzyme (ACE) activity. Whilst the mechanism to reduce type 2 diabetes is by inhibiting dipeptidyl peptidase IV (DPP-IV) action.

Keywords: ACE; DPP-IV inhibitor; antidiabetic; antihypertensive; antioxidant; bioactive peptide

Document Type: Review Article

Publication date: September 1, 2021

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  • Mini-Reviews in Organic Chemistry publishes original reviews on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly. Mini-reviews will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts.

    The journal is essential reading to all organic chemists in both academia and industry.
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