Skip to main content
padlock icon - secure page this page is secure

Bioactive Silver(I) Complexes with Phenolic Derivatives of Thioglycolic and Thiopropionic Acids

Buy Article:

$68.00 + tax (Refund Policy)

Ag(I) complexes formed by polydentate phenolic derivatives of thioglycolic and thiopropionic acids with Ag(I) ions could be a promising field of search for potential chemotherapeutic agents. Convenient synthetic methods to prepare these ligands have been developed on the basis of addition reactions occurring between S-nucleophiles and obenzoquinones. The results are presented of physicochemical investigation of Ag(I) ions complexation with phenolic ligands, which made it possible to determine ionic and redox ligand forms with high nucleophilicity of metal-ion binding sites, the peculiarities of the structural organization of the coordination cores of the newly synthesized complexes. The investigation of the molecular and electronic structure of Ag(I) complexes has been performed within the density functional theory framework. On the basis of the pharmacological screening results the selection is justified of a lead compound possessing antibacterial, antifungal and antiherpetic activity comparable to those of some standard drugs to develop effective pharmaceuticals for combination therapy of mixed infections. Data have been obtained on the ability of some phenolic derivatives of thioglycolic and thiopropionic acids as well as their Ag(I) complexes to reduce bovine cytochrome c.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Antimicrobial activity; DFT calculations; antiviral activity; cyclic voltammetry; cytochrome c; phenolic ligands; silver complexes

Document Type: Research Article

Publication date: August 1, 2013

More about this publication?
  • Mini-Reviews in Organic Chemistry publishes original reviews on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly. Mini-reviews will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts.

    The journal is essential reading to all organic chemists in both academia and industry.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more