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Recent Progress on Synthesis of Fluorescein Probes

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After its first synthesis in 1871, fluorescein and its derivatives have been used as a powerful tool for molecular and cellular studies in biology, molecular biology, interactions between ligands and macromolecules, for drug discovery and environmental research. In recent 20 years, research attention has been paid particularly to synthesis and separation of fluorescein derivatives having various linker groups. This mini-review briefly summarizes synthesis of fluorescein derivatives for improving their chemical, fluorescent and biological properties and conjugation suitability.

Keywords: Fluorescein; fluorescence spectroscopy; fluorescent dye; fluorescent probe

Document Type: Research Article

Publication date: February 1, 2009

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  • Mini-Reviews in Organic Chemistry publishes original reviews on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly. Mini-reviews will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts.

    The journal is essential reading to all organic chemists in both academia and industry.
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