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Development of Core-Corona Type Polymeric Nanoparticles as an Anti-HIV-1 Vaccine

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We developed a novel technology for core-corona polymeric nanoparticles having hydrophilic polymer chains with functional groups. Polystyrene nanoparticles immobilized with the mannose-specific lectin concanavalin A could efficiently capture human immunodeficiency virus type 1 (HIV-1) particles and gp120 antigens on their surface. Since the antigen-capturing nanoparticles were capable of inducing humoral and cellular immune responses to HIV-1, they could be developed as a mucosal vaccine against HIV-1 infection.





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Keywords: HIV-1; Polystyrene nanoparticles; concanavalin A; mucosal vaccine

Document Type: Research Article

Affiliations: Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.

Publication date: 01 February 2007

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