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Functional Correlation of Medicinal Chemistry and Entamoeba histolytica Treatment: An Emphasis on the Past, Present and Future Chemotherapy

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Entamoeba being an internal parasite is the causative organism of many human and animal infections with lethal consequences. Chemotherapy against Entamoeba was well established by both synthetic and natural products. Vigorous attainments were made by different researchers all over the world for discovering better chemical entities and the potent formulations. Preexisting compounds were developed into non-cytotoxic and with an enhanced therapeutic compounds by usage of multiparametric optimization techniques like QSAR, and molecular docking. The present review is therefore an aerial perspective of importance of medicinal chemistry in anti-amoebic chemotherapy. The review elucidates the existing synthetic compounds, their analogues, natural products, in silico studies and some novel methods adopted for the drug design as anti-amoebic agents which would be of assured benefit in the future drug design.
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Keywords: Anti amoebic agents; Entamoeba histolytica; QSAR

Document Type: Research Article

Publication date: March 1, 2015

More about this publication?
  • The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

    The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

    Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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