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Recent Advances in Computational Studies on Influenza A Virus M2 Proton Channel

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The matrix protein 2 of the influenza A virus (M2 or AM2) is one of the important components of the viral membrane. This protein can form a proton channel in the viral envelope. Owing to its ability to regulate the surrounding pH in endosome, this protein is an attractive target for drug design against influenza A virus. In this minireview, we summarized the current progresses in computational approaches for studying the M2 proton channel. The attention is focused on how protons are conducted through the M2 channel, and how adamantane-based drugs inhibit the channel, as well as how the drug resistance occurs, in hope to further stimulate the in-depth studies of this important area, both experimentally and theoretically.
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Keywords: Influenza A virus; M2 proton channel; drug binding site; drug inhibition; drug resistance; molecular dynamics; molecular modeling; proton conductance

Document Type: Research Article

Publication date: September 1, 2012

More about this publication?
  • The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

    The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

    Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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