@article {Dove:2004:1389-5575:941,
title = "Structure-Activity Relationships of Histamine H2 Receptor Ligands+",
journal = "Mini Reviews in Medicinal Chemistry",
parent_itemid = "infobike://ben/mrmc",
publishercode ="ben",
year = "2004",
volume = "4",
number = "9",
publication date ="2004-11-01T00:00:00",
pages = "941-954",
itemtype = "ARTICLE",
issn = "1389-5575",
url = "https://www.ingentaconnect.com/content/ben/mrmc/2004/00000004/00000009/art00004",
doi = "doi:10.2174/1389557043403242",
keyword = "qsar, h2 receptor antagonists, site-directed mutagenesis, h2 receptor agonists, arpromidine, impromidine analogues, molecular modelling, structure-activity relationships",
author = "Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin",
abstract = "Recent research on histamine H2 receptor agonists was focused on quantitative structure-activity relationships and receptor models explaining the activity of imidazolylpropylguanidines. Their selectivity for guinea pig vs. human isoforms was investigated using H2 receptor-Gs fusion proteins and attributed to amino acid differences in transmembrane domains 1 and 7. New antagonists result from approaches to improve pharmacokinetic properties and to design hybrid drugs which additionally have gastroprotective or anti H. pylori activity.",
}