Homology-Based Modelling of Targets for Rational Drug Design
The current status in rational drug design using homology-based models is discussed, with focus on template selection, model building, model verification and strategies for drug design based on model structures. A novel approach for identification of unique binding site features from homology-based models, Protein Alpha Shape Similarity Analysis (PASSA) is described.
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Document Type: Review Article
Affiliations: Department of Cancer Research and Molecular Medicine, Faculty of Medicine, MTFS, Norwegian University of Science and Technology, N-7489 Trondheim, Norway
Publication date: September 1, 2004
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- The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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