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Enzyme Inhibitors in Biorational Approaches for Pest Control

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Conventional insecticides of broad spectrum have been widely used as the main tools for controlling insect pests. However, as the consequence of their toxicity and deep environmental impact, new biorational, and more specific approaches have been developed. In this review we present an overview of those pest control approaches which have resulted from studies dealing with inhibition of the enzymes involved in the physiology, growth, molting, development and reproduction of insect pests. These approaches involve synthetic compounds from laboratory studies and natural chemicals present in the crop plants. Recent developments using inhibitors expressed in transgenic plants are also outlined.
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Keywords: Biorational Approaches; Enzyme Inhibitors; toxicity

Document Type: Review Article

Affiliations: Department of Biological Organic Chemistry, IIQAB (CSIC), Jordi Girona 18-26. 08034 Barcelona Spain

Publication date: September 1, 2004

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  • The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

    The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

    Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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