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Inhibitors of Platelets Glycoprotein IIb / IIIa (GP IIb / IIIa) Receptor: Rationale for their Use in Clinical Cardiology

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The glycoprotein IIb / IIIa (GP IIb / IIIa) receptor is the most important receptor involved in platelet aggregation. A stable GP IIb / IIIa inhibition is required when a massive platelet activation triggers thrombosis. Three GP IIb / IIIa inhibitors are currently approved for clinical use: abciximab, tirofiban and integrilin. Their different pharmacodynamic and pharmacokinetic properties reflect a different efficacy in platelet inhibition.
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Keywords: acute coronary syndromes; atherosclerotic plaque; glycoprotein; percutaneous coronary intervention; platelet aggregation inhibitors

Document Type: Review Article

Affiliations: Istituto Clinico Humanitas via Manzoni 56, 20089 Rozzano, Milano, Italy

Publication date: September 1, 2004

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  • The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

    The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

    Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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