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Synthesis and Antioxidant Evaluation of Schiff Bases Derived from 2,6- Pyridinedicarboxylic Acid

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A series of novel Schiff bases derived from dipicolinic acid was synthesized and evaluated for antioxidant and iron chelating activity. In most cases Schiff bases derived from di-hydrazide showed higher antioxidant activity than the ones derived from mono-hydrazide and some of them are very promising considering the fact of being better antioxidants than the standards used in the investigation. For iron chelating activity substituents had a greater impact on the activity than mono or di-hydrazide skeleton.
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Keywords: Antioxidant; Bacillus; Clostridium; Schiff base; antibacterial; antifungal; antitumor; dipicolinic acid; metal chelating; pharmaceutical

Document Type: Research Article

Publication date: July 1, 2012

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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