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Synthesis and Biochemical Evaluation of a Range of 4-(n-alkanesulfonate) benzyl Imidazole-Based Compounds as Inhibitors of Rat Testicular 17α-hydroxylase/17,20-lyase (P45017) in the Treatment of Hormone- Dependent Prostate Cancer

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17α-Hydroxylase/17,20-lyase is a target in the treatment of hormone-dependent prostate cancer. Here we report the results of a study into a range of alkanesulfonate derivatives of 4-hydroxybenzylimidazole which show the compounds to be good inhibitors with 5 [IC50=1.11μM (17α-OHase) and IC50=1.28μM (lyase)] being the most potent but weaker than ketoconazole.

Keywords: 17α-OHase; 17α-hydroxylase/17; 20-lyase; Azole; Inhibitors Lyase

Document Type: Research Article

Publication date: October 1, 2014

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