Anionic Linear Globular Dendrimer-G2-Ciprofloxacin Nano-Conjugate: Novel Agent against Wilson Disease Cell Model
Inherited defect of the gene ATP7B causes malexcretion of copper in the bile and leads to several complications that need treatment to deplete it from organs. Current therapy of Wilson disease, D-penicillamine has very serious side effects and drug with optimum therapeutic effects and
minimum side effects is of importance. In the present study ciprofloxacin was conjugated with an anionic globular dendrimer to lower the intracellular copper concentration. The results showed its efficacy and safety to certain levels. Based on the results, ciprofloxacin-anionic linear globular
dendrimer conjugate can be a useful option to reduce intracellular copper concentration and an investigational therapeutic agent in Wilson disease.
Keywords: Copper; Dendrimer-ciprofloxacin nano-particle; Fluoroquinolone; Metal ions; Wilson disease
Document Type: Research Article
Publication date: 01 August 2014
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