Skip to main content
padlock icon - secure page this page is secure

Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity

Buy Article:

$63.00 + tax (Refund Policy)

Gram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones was synthesized and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial growth than methoxylated analogues. The compound 3’,5’,4-trihydroxychalcone is the most promising compound among those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 μg/ml to a multidrug- resistant hospital clinical strain of S. aureus.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Aldol condensation; Antimicrobial; Chalcone; Phenolic compound

Document Type: Research Article

Publication date: 01 June 2014

More about this publication?
  • Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more