Skip to main content
padlock icon - secure page this page is secure

Synthesis, Characterization, Antimicrobial Activity of Novel N-Substituted β-Hydroxy Amines and βHydroxy Ethers Contained Chiral Benzoxazine Fluoroquinolones

Buy Article:

$68.00 + tax (Refund Policy)

Synthesis of novel N-substituted β-hydroxy amines 4(a-j) and β-hydroxyethers 5(a-c) with chiral benzoxazine fluoroquinolones has been described. Benzoxazinefluoroquinolone carboxylic acid 1, on reaction with piperizine in acetonitrile in presence of triethylamine under reflux gives 7- piperazinyl benzoxazine fluoroquinolone 2. The latter is reacted with epichlrohydrine in presence of NaOH in acetone to yield respective N-substituted epoxide 3 with retained chirality, the 3 on treatment with different amines gives respective β-hydroxy amines 4(a-j). On other hand, 3 on treatment with alcohols in presence of NaOH afforded the corresponding β-hydroxy ethers 5(a-c). The structures of the synthesized compounds have been established on the basis of its spectral and analytical data. The antimicrobial activity of newly synthesized compounds ware evaluated against different microorganisms comparing with levofloxacin and found all the compounds exhibited remarkable activity.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: 7-Piperazinyl chiral benzoxazine fluoroquinolones; Antimicrobial activity; Chiral benzoxazine fluoroquinolones; Epichlorohydrine; FDA; Gram-positive; pharmacophore; piperazine ring; piperazinyl fluoroquinolones; spectrum antibiotics

Document Type: Research Article

Publication date: January 1, 2013

More about this publication?
  • Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more