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Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate

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Kinetic and crystallographic studies on the formation of the complex between iodoacetate and the enzyme glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi were conducted in order to investigate the mechanistic and structural basis underlying enzyme inactivation. The crystallographic complex reveal important structural features useful for the design of novel inhibitors.

Keywords: Enzyme; Glyceraldehyde-3-phosphate dehydrogenase; Inhibitors; Parasitic infections; Trypanosoma cruzi; X-ray crystallography

Document Type: Research Article

Publication date: April 1, 2009

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