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Free Content Selective Androgen Receptor Modulators Antagonize Apolipoprotein E4-Induced Cognitive Impairments

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While tissue specific effects of selective androgen receptor modulators (SARMs) outside the brain have been reported, little is known about brain specific SARMs. Here we show that SARMs upregulate androgen receptor levels in brain following castration and antagonize impairments in hippocampus-dependent novel location recognition and spatial memory retention in apoE4 female mice. Together with the reduced androgen levels in aged men and women and the beneficial effects of androgens on brain function and pathology in Alzheimer's disease-related models, these data support the therapeutic potential of SARMs for age-related cognitive decline and Alzheimer's disease.





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Keywords: Androgen receptor; Castration; Mouse; Object recognition; Open field; Water maze

Document Type: Research Article

Publication date: June 1, 2008

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  • Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.
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