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Synthesis and Evaluation of 2'-Substituted Fendiline Analogues as Antileukemics

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A series of novel, 2'-substituted derivatives of fendiline have been synthesised and their ability to inhibit growth of human leukaemia cells (K562) determined. Of these derivatives, the 2'-hydroxy compounds 26 and 27 had a significantly greater inhibitory effect on K562 cells than fendiline.

Keywords: Antileukemic compounds; Diphenylmethanes; Fendiline

Document Type: Research Article

Publication date: June 1, 2007

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  • Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.
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