Cancer Genetics and Drug Discovery in Mice
Different mouse models have been generated to understand the molecular mechanisms involved in human tumorigenesis. Some of these models are produced by gene-targeting procedures, whereas others use the normal mouse as an experimental animal. The pathogenetic relevance of these mouse models has generated optimism for the development of effective targeted therapies, advances in rational drug design and has provided valuable information about human cancer disease. By combining genetic analysis and molecule screening techniques, the mouse is emerging as a powerful system for identifying novel cancer genes and for cancer drug discovery. However, there are both parallelisms and discrepancies between mouse and human carcinogenesis important for elucidating the human disease process.
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Document Type: Review Article
Affiliations: Instituto de Biologia Molecular y Celular del Cancer (IBMCC), CSIC / Universidad de Salamanca, Campus Unamuno, 37007-Salamanca, Spain.
Publication date: October 1, 2004
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- Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.
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