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Free Content Effects of Peach (Prunus persica)-Derived Glucosylceramide on the Human Skin

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Background: Plant-derived ceramides are functional natural products with various physiological effects that improve water retention and skin permeability functions.

Objective: Herein, we isolated peach (Prunus persica)-derived glucosylceramide with high purity and evaluated its effects on moisture and permeability of skin.

Methods: Three separate experiments were performed: evaluations of the effect of peachderived glucosylceramide application on the ceramide content in a three-dimensional human cultured skin model, water retention effect of the oral administration of the peach-derived glucosylceramide on human skin functionality, and safety of the long-term administration of the peach-derived glucosylceramide in human subjects.

Results: Treatments of three-dimensional cultures of human skin with peach-derived glucosylceramide led to dose-dependent increases in human ceramide contents. Additionally, after oral administration of ceramide to humans, dose-dependent improvements in water retention functions of skin, suppression of trans-epidermal water loss and improvements in skin texture were observed. Furthermore, no significant changes in subjective/objective symptoms, physical characteristics, or laboratory test values were observed in human subjects following long term oral administration of ceramide at doses that were 4.5-9-times greater than recommended. Taken together, the present data indicate the positive effects of peach ceramide on skin function and no adverse effects.

Conclusion: Ingestion of peach ceramide safely improved the state of the skin.
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Keywords: Glucosylceramide; Prunus persica; moisturizing effect; open-label trial; skin function; skin texture; stratum corneum

Document Type: Research Article

Publication date: April 1, 2017

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  • Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in the medicinal chemistry and rational drug design for the discovery of new Immunology, Endocrine & Metabolic Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Immunology, Endocrine & Metabolic medicinal chemistry.

    Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Immunology, Endocrine & Metabolic drug discovery.
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