Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Patel, Sweta
AU - Mandaliya, Dipeeka
AU - Prajapati, Bhumika
AU - Kumar, Sunny
AU - Seshadri, Sriram
TI - Cefdinir Microsphere Modulated Microflora and Liver Immunological Response to Diet Induced Diabetes in Mice
JO - Endocrine, Metabolic & Immune Disorders - Drug Targets(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)
PY - 2019-05-01T00:00:00///
VL - 19
IS - 3
SP - 349
EP - 357
KW - inflammation
KW - Diabetes
KW - cefdinir
KW - gut microflora
KW - high carbohydrate diet
KW - Th1/Th17/Treg cells
N2 - Objective: Gut microbiota is currently targeted for various diseases especially metabolic disorders such as diabetes. Our strategy is to alter gut microflora via specific antibiotic to reduce load of inflammation in the liver that increases as a result of high carbohydrate diet. Th1,
Th17 and Treg are important immune cell types which decide the type of inflammatory response. Liver is tolerogenic in nature with low Th17/Treg ratio. In diabetics, this ratio decreases even more, and can cause liver trauma.
Method: The present study tries to find relationship between
gut flora and immune cells such as Th1/Th17/Treg and their role in liver metabolism using diet induced diabetic mice model.
Result: Upon alteration of flora using Cefdinir in different forms, one could help lower the level of Treg cells thus increasing the ratio. Gut flora is strongly
associated with the immunity in the liver. Targeted alteration of gut flora helps us to restore insulin sensitivity.
Conclusion: Colon targeted Cefdinir gives more promising results, opens colonic bacteria as target for improving gut, liver inflammation and insulin sensitivity.
UR - https://www.ingentaconnect.com/content/ben/emiddt/2019/00000019/00000003/art00014
M3 - doi:10.2174/1871530319666181224122115
UR - https://doi.org/10.2174/1871530319666181224122115
ER -