@article {Wasfy:2018:1871-5303:573,
title = "Predicting Esophageal Varices in Cirrhotic Hepatitis C Virus Patients Using Noninvasive Measurement of Insulin Resistance Variables",
journal = "Endocrine, Metabolic & Immune Disorders - Drug Targets(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)",
parent_itemid = "infobike://ben/emiddt",
publishercode ="ben",
year = "2018",
volume = "18",
number = "6",
publication date ="2018-11-01T00:00:00",
pages = "573-580",
itemtype = "ARTICLE",
issn = "1871-5303",
url = "https://www.ingentaconnect.com/content/ben/emiddt/2018/00000018/00000006/art00005",
doi = "doi:10.2174/1871530318666180803120428",
keyword = "non-invasive, Insulin resistance, portal hypertension, esophageal varices, HOMA-IR score, cirrhotic hepatitis C virus",
author = "Wasfy, Elsaid and Elkassas, Galal and Elnawasany, Sally and Elkasrawy, Kariman and Abd-Elsalam, Sherief and Soliman, Shaimaa and Badawi, Rehab",
abstract = "Background & Aims: Esophageal varices (EV) are a major complication of portal hypertension in cirrhotic patients. Screening is essential for all patients with cirrhosis. Performing non-invasive methods for screening is a cost-effective and time-saving measure. The aim of this work
is to evaluate whether insulin resistance (IR) assessed by HOMA-IR score can predict the presence of EV or not. Methods: This cross-sectional study was carried out on sixty Egyptian cirrhotic HCV patients divided into 3 groups: Group I: 20 cirrhotic patients without esophageal varices,
Group II: 20 cirrhotic patients, with small esophageal varices and Group III: 20 cirrhotic patients with large esophageal varices. Fasting insulin level was measured and HOMA- IR score was calculated. Abdominal ultrasound and Fibroscan were done to all patients. Results: Insulin resistance
assessed by HOMA IR score showed a statistically significant difference among the three groups (P<0.001) with a cutoff value equal to or more than 3.40. It could significantly predict EV (AUROC= 0.841) with high sensitivity of 75 %, and excellent specificity 80%. Liver stiffness
measurement (LSM) with a cutoff value 40.95 kPa could significantly predict EV (AUROC= 0.629) with sensitivity 75 %, specificity 50 %. Conclusion: HOMA-IR score is a new independent predictor of the presence of EV.",
}