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The Association between Metabolic Syndrome and Serum Levels of Adiponectin and High Sensitive C Reactive Protein in Gorgan

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Background: The aim of this study was to assess serum levels of highly sensitive C-reactive protein (hs-CRP) and adiponectin in subjects with metabolic syndrome and control groups.

Methods: There were 40 subjects with metabolic syndrome and 40 control groups. Mean serum level of adiponectin and high sensitive C reactive protein were lower and higher in subjects with metabolic syndrome than control groups, respectively. There were significant positive correlation between high sensitive C reactive protein and waist circumference, systolic and diastolic blood pressure, triglyceride and fasting blood glucose. There were significant negative correlation between adiponectin and waist circumference and triglyceride. Hs-CRP showed a stronger association with metabolic syndrome than adiponectin.

Results: Our findings suggest that elevated hs-CRP and reduced adiponectin showed positive and negative association with some metabolic syndrome components. Hs-CRP showed a stronger association with the metabolic syndrome than adiponectin.

Conclusion: It seems that hs-CRP may play a significant role as a risk factor for metabolic syndrome. In this study, in contrast with other findings it may suggest that hs-CRP is more important as a diagnostic biomarker for metabolic syndrome than adiponectin. These differences may be due to the changes in the lifestyle and dietary habits in subjects with metabolic syndrome in Gorgan inhabitants. It likes that these subjects do less physical activity and use more fatty nutrients. It seems that subjects with metabolic syndrome need to change their life style and dietary habits in this area to halt the burden of cardiovascular complications.
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Keywords: Adiponectin; gorgan; high sensitive C reactive protein; metabolic syndrome

Document Type: Research Article

Publication date: June 1, 2016

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  • This journal is devoted to timely reviews of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Topics related to the neuroendocrine-immune axis are given special emphasis in view of the growing interest in stress-related, inflammatory, autoimmune, and degenerative disorders.
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