@article {Kutluturk:2013:1871-5303:163,
title = "Association of Cytokine Gene Polymorphisms (IL6, IL10, TNF-, TGF- and IFN-) and Graves Disease in Turkish Population",
journal = "Endocrine, Metabolic & Immune Disorders - Drug Targets(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)",
parent_itemid = "infobike://ben/emiddt",
publishercode ="ben",
year = "2013",
volume = "13",
number = "2",
publication date ="2013-06-01T00:00:00",
pages = "163-167",
itemtype = "ARTICLE",
issn = "1871-5303",
url = "https://www.ingentaconnect.com/content/ben/emiddt/2013/00000013/00000002/art00004",
keyword = "polymorphism, transforming growth factor, graves’ disease, interferon, Cytokine, interleukin, tumour necrosis
factor",
author = "Kutluturk, Faruk and Yarman, Sema and Sarvan, Fatma O. and Kekik, Cigdem",
abstract = "Introduction: Cytokines play a crucial role in the pathogenesis of autoimmune thyroid disease, and recent studies have demonstrated an association between cytokine gene polymorphisms and Graves Disease (GD) in different ethnic groups. The aim of the present study was to investigate
the relationship of interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-), transforming growth factor-beta (TGF-), and interferon-gamma (INF-) gene polymorphisms in the development of GD in Turkish population. Material and Methods: A total of 224 subjects were
included in the study comprising of 100 patients with GD (70 female, 30 male; mean age, 43.9 \textpm13.8 years) and 124 healthy subjects (81 female, 43 male); mean age, 37.8 \textpm10.2 years) without antithyroid autoantibodies or family history of autoimmune disorders. Genotyping was conducted
by using PCR and sequence-specific primers. Results: Statistical analysis showed a significant association between high TNF- -308GA and IL-6 -174CC gene polymorphisms in patients with GD compared to control subjects (p=0.016, p=0.044, respectively). However, no significant differences
were observed between GD and control subjects for IL-10, TGF-, and INF- gene polymorphisms. Conclusion: TNF--308GA and IL-6 -174CC gene polymorphisms are involved in susceptibility to GD in Turkish population. The polymorphism hypothesis in pro-inflammatory cytokines
might be involved in predisposition to GD.",
}